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As with any drug product, there may be side effects. The most commonly reported side effects in patients treated with Cialis during the testing of the product were: headache tadalafil side effect Tadalafil is a medicine that relaxes blood vessels and treats erectile dysfunction, benign prostatic hypertrophy, and pulmonary arterial hypertension. Learn about the warnings, interactions, and common side Headache: This adverse effect is the most commonly reported side effect, likely due to tadalafil’s vasodilatory impact on cerebral blood vessels. Headaches induced by tadalafil range from mild to severe and are generally transient.

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